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  melior melior discovery melior pharmaceuticals preclinical services pre-clinical services in vivo pharmacology in vivo efficacy efficacy models pharmacokinetics indications discovery specialized animal models bioanalytical services theratrace exton pennsylvania cro contract research drug discovery drug development metabolic disease alzheimer’s alzheimers diabetes reprofiling    

Melior Discovery in vivo efficacy models and drug safety

in vivo Efficacy Models
Melior is a leading contract research provider of in vivo pharmacology services, using rats, mice, and guinea pigs.

Cardiovascular

Bleed Time Assay and Anti-Thrombotic Model

Hypertension Model and Telemetry Assay

 

Fibrosis

Liver Fibrosis Model

Pulmonary Fibrosis Model

 

Gastrointestinal

Colonic Motility Model

DSS Model of Colitis

Gastrointestinal Transit Model

IBS Model and Acetylcholine Writhing Assay

Morphine - Induced Constipation Assay

 

Hair Growth and Dermatitis

Allergic Contact Hypersensitivity

Alopecia Model and Hair Growth Assay

Delayed Type Hypersensitivity

Pruritus Scratching Model

 

Inflammation and Arthritis

Arthritis Models

Collagen - Induced Arthritis

Sensitivity Models

Allergic Contact Hypersensitivity

Capsaicin Hyperalgesia Assay

Delayed Type Hypersensitivity

Formalin Analgesia Assay

Inflammation Models

Acute Nephritis Model

Acute Pancreatitis Model

Pulmonary Allergic Asthma Model

EAE Model of Multiple Sclerosis

LPS - Pulmonary Inflammation

LPS - Systemic Inflammation

Monocyte Infiltration

Zymosan- A Induced Acute Peritonitis Model

 

Metabolic

Appetite Suppressant Assays

Food Intake

Diabetic Models

db/db Mouse Model of Type II Diabetes

ob/ob Mouse Model of Type II Diabetes

Streptozotocin Insulin-Depleted Rat Model

Insulin Sensitivity Assays and Models

Euglycemic / Hyperglycemic Clamp Study

Insulin Tolerance Test (ITT)

Oral Glucose Tolerance Test

Obesity Assays and Models

DEXA - Bone Mineral Density Scan

Diet-Induced Obesity Model

Diet-Induced Obesity Model / High Fat Diet

 

Motor Function

Grip Strength Test
Harmaline-induced Tremor

Locomotor and Open-Field Activity

Motor Evoked Potentials

Rotarod Test

 

Urogenital

Micturition, Overactive Bladdar, Urinary Incontinence

melior

Neurology

Multiple Sclerosis Models

EAE Model of Multiple Sclerosis

Parkinson's Disease Models

6-OHDA Rat Model of Parkinson's Disease

Haloperidol-Induced Catalepsy Model

MPTP-Induced Mouse Model of Parkinson's Disease

Seizure Assays and Models

6 Hz Psychomotor Seizure Model

Audiogenic Seizure in Fmr1 Knockout Mice

Maximal Electroshock Test for Clonic/Tonic Seizure

Pentylenetetrazole-Induced Seizure Model

Sensorimotor Assays

Startle Prepulse Inhibition

       

 

Neurophysiology

EEG Frequency and Analyses

Cortical EEG Frequency

Pro-and Anti-Convulsant Evaluation

Sleep/Wake and Motor Activity

Status Epilepticus Epilepsy Model

Evoked Potentials

Cortical Sensory Evoked Potentials

Motor Evoked Potentials

Reflex Response

C-fiber Pain Reflex

Proprioceptive Spinal Reflexes

Single Unit Recording

STN Recording in 6-OHDA-Lesioned Rats

 

Pain / Neuropathic

Algesia Assays and Models

Capsaicin Hyperalgesia Assay

Formalin Analgesia Assay

Hargreaves Hyperalgesia Assay

Hot Plate Thermal Analgesia Assay

Tail - Flick Thermal Analgesia Assay

Tail Immersion Thermal Analgesia Assay

Neuropathic and Pain Models

Chronic Constrictive Injury Model

Diabetic Neuropathy: Streptozotocin Insulin-Depleted Rat Model

IBS Model and Acetylcholine Writhing Assay

Migraine Model

Spinal Nerve Ligation Model

von Frey / Carrageenan Allodynia Assay

 

Psychiatric and Cognitive

Anxiety Assays and Models

Elevated Plus Maze Anxiety Assay

Light/Dark Transitions and Anxiety Model

Chronic Mild Stress Assays

Corticosterone Assay

Stress - Induced Hyperthermia

Tail Suspension Test

Depression Assays and Models

Forced Swim Test and Depression Model

Tail Suspension

Learning and Memory Assays and Models

Fear Conditioning

Morris Water Maze

Novel Object Recognition Test

Social Recognition

Sensorimotor Assays and Models

Open - Field Activity

Rotarod

Startle Prepulse Inhibition

 

 

Drug Safety Assessment
Melior is a leading contract research provider of in vivo pharmacology services, using rats, mice, and guinea pigs.

 

Drug Abuse Liability

Conditioned Place Preference

Drug Discrimination

Locomotor Sensitization

Self Administration

Withdrawal / Dependence

 

Seizure Potential

6-Hz Psychomotor Seizure Model

Audiogenic Seizure in Fmr1 KO Mice

EEG Pro- and Anti- Convulsant Evaluation

Maximal Electroshock

Pentelenetetrazole-Induced Seizure

Status Epilepticus Epilepsy Model

General Drug Safety Assessment

Irwin

Open - Field Activity

Rotarod

   

 

If you are interested in learning more about Melior Discovery's in vivo efficacy models or drug safety assessment, please contact models@meliordiscovery.com to start the conversation.