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melior melior melior discovery melior pharmaceuticals preclinical services pre-clinical services in vivo pharmacology in vivo efficacy efficacy models pharmacokinetics indications discovery specialized animal models bioanalytical services theratrace exton pennsylvania cro contract research drug discovery drug development metabolic disease alzheimer’s alzheimers diabetes reprofiling

Melior Discovery articles of interest

Cell and Small Animal Models of Phenotypic

Drug Discovery

By Mihaly Szabo, Sara Svensson Akusjärvi, Ankur Saxena,
Jianping Liu, Gayathri Chandrasekar, Satish S. Kitambi
 
Drug Design, Development & Theory, June 2017

The phenotype-based drug discovery (PDD) approach is re-emerging as an alternative platform for drug discovery.

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Therapeutic Drug Repurposing, Repositioning and Rescue  Part II: Business Review

By Dr Stephen Naylor, David M. Kauppi & Judge M. Schonfeld
Drug Discovery World, Spring 2015

There is an emerging consensus that the impact of Drug Repurposing, Repositioning and Rescue (DRPx) on the pharmaceutical industry is real and sustainable.

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                                                  Download PDF reproduced with kind permission of Drug Discovery World

Lazarus Drugs

By Kate Yandell  | The Scientist, February 1, 2015

While some drugs sail through development, others suffer setbacks, including FDA rejections, before reaching the market.

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Therapeutic Drug Repurposing, Repositioning and Rescue  Part I: Overview

By Dr Stephen Naylor and Judge M. Schonfeld
Drug Discovery World, Winter 2014

The pharmaceutical industry is still beleaguered by escalating costs, stagnant productivity and protracted timelines as it struggles to bring therapeutic drugs to market.

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                                                  Download PDF reproduced with kind permission of Drug Discovery World

How were new medicines discovered?

By David C. Swinney & Jason Anthony
Nature Reviews Drug Discovery, July 2011

Preclinical strategies that are used to identify potential drug candidates include target-based screening, phenotypic screening, modification of natural substances and biologic-based approaches. To investigate whether some [...]

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A Forensic Analysis of Drug Targets From 2000 Through 2012

By B. Munos | Clinical Pharmacology & Therapeutics June 2013

Pharmaceutical innovation is often measured by counting the new drugs approved by regulators. It is a simple and useful metric, but it has shortcomings. One of them is that it says little about the drugs’ innovativeness. [...]

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Exploiting Complexity and the Robustness of Network Architecture for Drug Discovery

By Marc K. Hellerstein | JPET, January 2008

The issue of complexity stands at the center of contemporary drug discovery and development. The central problem in drug development today is attrition of drug candidates identified by the modern molecular target-based discovery approach [...]

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Christopher Lipinski Rule of Five Melior Discovery

Christopher Lipinski, PhD Named in Top Ten Most Influential People in Pharma

World Pharmaceutical Fronteirs 2007 Edition Pharma 40

The Pharma 40 has been a great opportunity to evaluate the figures who have the bigest impact on our industry - an to see the sheer scope of their different influences.  But when the votes came in, we had to triple-check our figures - not just for accuracy, but because the top spot was such a surprise [...].

 

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Chris Lipinksi Presentation

By Chris Lipinski

Rules and Filters and their Impact on Success in Chemical Biology and Drug Discovery", in Arkin, M.R. (ed.), Small Molecule Drug Discovery:, The Biomedical & Life Sciences Collection, Henry Stewart Talks, Ltd, London [...]

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