Melior Discovery articles of interest
By Dr Stephen Naylor, David M. Kauppi & Judge M. Schonfeld
There is an emerging consensus that the impact of Drug Repurposing, Repositioning and Rescue (DRPx) on the pharmaceutical industry is real and sustainable.
By Kate Yandell | The Scientist, February 1, 2015
While some drugs sail through development, others suffer setbacks, including FDA rejections, before reaching the market.
By Dr Stephen Naylor and Judge M. Schonfeld
The pharmaceutical industry is still beleaguered by escalating costs, stagnant productivity and protracted timelines as it struggles to bring therapeutic drugs to market.
By David C. Swinney & Jason Anthony
Preclinical strategies that are used to identify potential drug candidates include target-based screening, phenotypic screening, modification of natural substances and biologic-based approaches. To investigate whether some [...]
By B. Munos | Clinical Pharmacology & Therapeutics June 2013
Pharmaceutical innovation is often measured by counting the new drugs approved by regulators. It is a simple and useful metric, but it has shortcomings. One of them is that it says little about the drugs’ innovativeness. [...]
By Marc K. Hellerstein | JPET, January 2008
The issue of complexity stands at the center of contemporary drug discovery and development. The central problem in drug development today is attrition of drug candidates identified by the modern molecular target-based discovery approach [...]
World Pharmaceutical Fronteirs 2007 Edition Pharma 40
The Pharma 40 has been a great opportunity to evaluate the figures who have the bigest impact on our industry - an to see the sheer scope of their different influences. But when the votes came in, we had to triple-check our figures - not just for accuracy, but because the top spot was such a surprise [...].
By Chris Lipinski
Rules and Filters and their Impact on Success in Chemical Biology and Drug Discovery", in Arkin, M.R. (ed.), Small Molecule Drug Discovery:, The Biomedical & Life Sciences Collection, Henry Stewart Talks, Ltd, London [...]