melior melior discovery melior pharmaceuticals preclinical services pre-clinical services in vivo pharmacology in vivo efficacy efficacy models pharmacokinetics indications discovery specialized animal models bioanalytical services theratrace exton pennsylvania cro contract research drug discovery drug development metabolic disease alzheimer’s alzheimers diabetes reprofiling
Melior Discovery
home
Therapeutic Areas
Safety Assessment
 

 

theraTRACE

Melior Pharmaceuticals

              

 

             

 

                 

melior melior melior discovery melior pharmaceuticals preclinical services pre-clinical services in vivo pharmacology in vivo efficacy efficacy models pharmacokinetics indications discovery specialized animal models bioanalytical services theratrace exton pennsylvania cro contract research drug discovery drug development metabolic disease alzheimer’s alzheimers diabetes reprofiling

Melior Discovery cardiovascular

Blood Pressure-Telemetry
Primary hypertension is a chronic medical condition in which the arteriole blood pressure is constantly elevated with no apparent medical cause such as kidney diseases, tumors or medication side effects. Spontaneous hypertensive rats (SHR) are one of the most commonly used animal models for primary hypertension. These rats exhibit elevated blood pressure beginning at 6 weeks of age. Telemetry methods allow for the continuous and stress free measurement of blood pressure parameters including diastolic, systolic, mean arterial pressure, pulse pressure and pulse.

Seven hours after administration, Candesartan significantly attenuated arterial blood pressure (A-B) in spontaneous hypertensive rats (*p<0.05) while vehicle treated rats maintained elevated blood pressure.  Data are mean ± SEM; *p<0.05 compared to vehicle.

 

If you are interested in learning more about the Blood Pressure - Telemtry Assay, please contact models@meliordiscovery.com to start the conversation.