Melior Discovery cardiovascular
Primary hypertension is a chronic medical condition in which the arteriole blood pressure is constantly elevated with no apparent medical cause such as kidney diseases, tumors or medication side effects. Spontaneous hypertensive rats (SHR) are one of the most commonly used animal models for primary hypertension. These rats exhibit elevated blood pressure beginning at 6 weeks of age. Telemetry methods allow for the continuous and stress free measurement of blood pressure parameters including diastolic, systolic, mean arterial pressure, pulse pressure and pulse.
Seven hours after administration, Candesartan significantly attenuated arterial blood pressure (A-B) in spontaneous hypertensive rats (*p<0.05) while vehicle treated rats maintained elevated blood pressure. Data are mean ± SEM; *p<0.05 compared to vehicle.
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