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theraTRACE

theraTRACE

Melior Pharmaceuticals

melior melior melior discovery melior pharmaceuticals preclinical services pre-clinical services in vivo pharmacology in vivo efficacy efficacy models pharmacokinetics indications discovery specialized animal models bioanalytical services theratrace exton pennsylvania cro contract research drug discovery drug development metabolic disease alzheimer’s alzheimers diabetes reprofiling

Melior Discovery hair growth & dermatitis

Hair Growth Assay
Alopecia is the medical description for the loss of hair from the head or the body.   There are many forms of alopecia, with androgenic alopecia and alopecia areata being the most common.   Although alopecia is not life-threatening, it can be life-altering and can produce profound psychological impact on those afflicted by the disease. There are several drugs that promote hair growth including Minoxidil. The data below show the effects of hair regrowth in our validated mouse model.

                          

Hair Growth Assay.  After hair removal, mice were administered Minoxidil or vehicle for 25 days and hair re-growth monitored and visually scored. The figure shows the time course of hair re-growth and the effects of Minoxidil.  (As early as 11 days after initial treatment Minoxidil significantly increased hair growth relative to vehicle treatment (***p<0.001). This effect was sustained throughout the study. Data are mean ± SEM; ***p<0.001 compared to vehicle.

 

Scoring system:  Hair growth scoring system: 1- initial state; 2- short, visible hair; 3- sparse, long hair; 4- dense, long hair; 5- complete hair growth.

 

If you are interested in learning more about the Hair Growth Assay, please contact models@meliordiscovery.com to start the conversation.