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melior melior melior discovery melior pharmaceuticals preclinical services pre-clinical services in vivo pharmacology in vivo efficacy efficacy models pharmacokinetics indications discovery specialized animal models bioanalytical services theratrace exton pennsylvania cro contract research drug discovery drug development metabolic disease alzheimer’s alzheimers diabetes reprofiling

Melior Discovery inflammation/arthritis

Capsaicin Analgesia Assay
Direct injection of capsaicin to rodents induces a hyperalgesic response through activation of the vanilloid receptor. Capsaicin-mediated pain is responsive to a variety of analgesic compounds including morphine. We use the capsaicin hyperalgesic assay to evaluate efficacy of compounds for analgesic activity.    

                          

Rats were evaluated for baseline thresholds before initiating treatment.  Seven days after baseline testing, rats were treated with capsaicin to induce hyperalgesia and increase sensitivity in the hind paws.  One half hour before testing, rats were treated with either vehicle or morphine.  Rats that were treated with vehicle had significantly reduced thresholds compared to baseline.  Morphine treated rats had significantly increased thresholds and reduced sensitivity compared to vehicle treated rats.   Data are mean ± SEM; ***p<0.001 compared to baseline, +++p<0.001 compared to vehicle.

 

if you are interested in learning more about the Capsaicin Analgesia Assay, please contact models@meliordiscovery.com to start the conversation.