Melior Discovery inflammation/arthritis
Allergic asthma is a condition that is initiated by an immune response to a diverse array of allergens and is manifested by airway obstruction, hyper-reactivity, and lung inflammation. This asthmatic response can be mimicked in experimental animals by sensitizing and then exposing them to an array of antigens. Like the asthmatic response in humans, the animal model of pulmonary inflammation is characterized by an extensive inflammatory response including an influx of leukocytes including monocyte chemoattractant protein (MCP-1). This inflammatory response can be attenuated by administration of a number of known anti-inflammatory agents.
After initial sensitization and challenge, vehicle-treated animals showed a significant increase in MCP-1 compared to untreated animals, indicating an allergic inflammatory response. Administration of dexamethasone significantly attenuated the inflammation response so that, while MCP-1 levels where higher than untreated animals, they were significantly lower than vehicle-treated animals. Data are mean ± SEM; *p<0.05, ***p<0.001 (compared to untreated animals); +p<0.05 (compared to vehicle-treated animals).
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