Melior Discovery inflammation/arthritis
Average combined clinical score of all four paws. Clinical scores were assessed five days a week beginning on Day 27 and ending on Day 42.
Clinical Scoring Scale:
0: No clinical signs; normal activity
1: Hind or forepaw joint affected or minimal diffuse erythemia / swelling
2: Hind or forepaw joints affected or mild diffuse erythemia / swelling
3: Hind or forepaw joitns affected or moderate diffuse erythemia / swelling
4: Marked diffuse erythmia / swelling or digital joints affected
5: Severe diffuse erythmia / swelling of the entire paw, unable to flex digits
Based on the clinical score system, vehicle treated mice displayed an increase in inflammation severity throughout the course of the study. The Dexamethasone treated mice displayed a significant decrease in inflammation following drug administration that continued throughout the dosing period of fourteen days when compared to vehicle treated mice. Dexamethasone is a potent cortiosteroid and reversed RA symptoms. Untreated sham mice maintained a clinical score of 0 throughout the study. Data are mean ± SEM; ** = p<0.01 compared to vehicle.