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melior melior melior discovery melior pharmaceuticals preclinical services pre-clinical services in vivo pharmacology in vivo efficacy efficacy models pharmacokinetics indications discovery specialized animal models bioanalytical services theratrace exton pennsylvania cro contract research drug discovery drug development metabolic disease alzheimer’s alzheimers diabetes reprofiling

Melior Discovery metabolic

Diet-Induced Obesity
Obesity is a condition of pandemic proportions in the modern world. A myriad of conditions ranging from cardiovascular disease, type-2 diabetes, cancer, and even depression have been linked to obesity. Research into the mechanisms and treatment of obesity is an ongoing area of interest to many in the pharmaceutical and academic communities. Animal models have proven useful in studying the effects of compounds on diet-induced obesity.

At Melior we utilize a high fat diet platform to model a number of acute and chronic features of metabolic and obesity disorders consistent with diet induced obesity changes in humans.

                                   diet-induced obesity DIO body weight obesity mouse model of obesity melior discovery

During a 14 day standardized high fat diet study, vehicle-treated animals gained significantly more weight than animals treated with rimonabant, an anti-obesity drug.

 

lean mass fat mass mouse model of obesity DEXA melior discovery

 

 

On day 11, animals were given a dual-energy x-ray absorptiometry (DEXA) scan to determine the percentage of lean body mass verses body fat. Both vehicle and rimonabant- treated animals had identical proportions of lean body mass while vehicle- treated animals had a significantly higher proportion of body fat.

 

Together these data indicate over time, on a high fat diet, animals gain body weight, primarily fat, and these effects can be attenuated by treatment with rimonabant.  Data are mean ± SEM; *p<0.05 compared to vehicle.

 

If you are interested in learning more about Diet-Induced Obesity, please contact models@meliordiscovery.com to start the conversation.