melior melior discovery melior pharmaceuticals preclinical services pre-clinical services in vivo pharmacology in vivo efficacy efficacy models pharmacokinetics indications discovery specialized animal models bioanalytical services theratrace exton pennsylvania cro contract research drug discovery drug development metabolic disease alzheimer’s alzheimers diabetes reprofiling
Melior Discovery
home
Therapeutic Areas
Safety Assessment
 

theraTRACE

Melior Pharmaceuticals

melior melior melior discovery melior pharmaceuticals preclinical services pre-clinical services in vivo pharmacology in vivo efficacy efficacy models pharmacokinetics indications discovery specialized animal models bioanalytical services theratrace exton pennsylvania cro contract research drug discovery drug development metabolic disease alzheimer’s alzheimers diabetes reprofiling

Melior Discovery metabolic

Diet-Induced Obesity/ High Fat Diet
High fat diets in rodents change multiple biochemical and physiological parameters that reflect the biochemical and physiological changes observed in obesity. Such diets induce dramatic changes in weight concomitant with elevations in serum cholesterol, lipids and tricglycerides. Moreover, these high fat diets can lead to atherosclerotic lesions as well as insulin resistance consistent with obesity-induced changes in humans.

At Melior, we have characterized a mouse model of induced-obesity by chronically feeding mice a modified high fat diet (Western Diet) that was designed to approximate the typical human diet of North America and Europe. This chronic assay also serves as a platform for a number of additional acute and subchronic assays designed to model various features of metabolic and obesity disorders consistent with diet-induced changes in humans.

 

               DIO diet-induced obesity high fat diet weight mouse model of obesity melior discovery

 

          high fat diet diet-induced obesity obesity model leptin levels melior discovery

The above data show changes in weight (top) and leptin (bottom) levels across time for animals fed either a normal diet or a high fat ‘Western style’ diet. Across time, animals fed a Western diet exhibited higher levels of both weight gain and leptin levels similar to physiological changes humans undergo with diet-induced obesity.  Data are mean ± SEM; *p<0.05 compared to normal diet.

 

If you are interested in learning more about Diet-Induced Obesity/High Fat Diet, please contact models@meliordiscovery.com to start the conversation.