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Melior Discovery metabolic

Food Intake
Food intake and the pattern of food intake over time is a useful means for determining the appetite suppressive effects of pharmacological agents. Antidepressants, specifically those that inhibit monoamine reuptake, have recently been found to be effective agents in reducing feeding behavior in mice and in the clinic.      

 appetite suppressent imipramine food intake antidepressants melior discovery

The graphs above illustrate the appetite suppressant effects of Imipramine over seven days. Relative to Imipramine, vehicle-treated animals consumed more food daily (A) and cumulatively across multiple days (C). Additionally, after fasting imipramine maintained an appetite suppressant effect (B) where vehicle- treated animals consumed significantly more food both 3 and 24 hours after being food deprived.  Data are mean ± SEM; *p<0.05 compared to vehicle.

 

If you are interested in learning more about Food Intake, please contact models@meliordiscovery.com to start the conversation.