Melior Discovery metabolic
ob/ob Mouse Model
Type II diabetes is characterized by high blood glucose levels in the presence of normal amounts of insulin. There are many animal models of type II diabetes that involve administering high levels of glucose to otherwise normoglycemic mice. ob/ob mice express mutations in leptin that lead to decreased leptin activity and decreased insulin receptor sensitivity. Subsequently these mice display increases in blood glucose levels, decreases in β-cell function, obesity and elevated HBA1c levels; consistent with the development of Type II diabetes. Using this model we can test the ability of a compound to effectively regulate this hyperglycemic response.
The graph illustrates the difference in response to a blood glucose challenge in ob/ob mice treated with vehicle or rosiglitazone – an insulin sensitizer and antidiabetic drug. Ob/ob mice administered rosiglitazone show significantly lower blood glucose across time relative to vehicle treated mice. Data are mean ± SEM; * p<0.05, **p<0.01 compared to vehicle.
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