melior melior discovery melior pharmaceuticals preclinical services pre-clinical services in vivo pharmacology in vivo efficacy efficacy models pharmacokinetics indications discovery specialized animal models bioanalytical services theratrace exton pennsylvania cro contract research drug discovery drug development metabolic disease alzheimer’s alzheimers diabetes reprofiling
Melior Discovery
home
Therapeutic Areas
Safety Assessment
 

theraTRACE

Melior Pharmaceuticals

              

 

             

 

                 

melior melior melior discovery melior pharmaceuticals preclinical services pre-clinical services in vivo pharmacology in vivo efficacy efficacy models pharmacokinetics indications discovery specialized animal models bioanalytical services theratrace exton pennsylvania cro contract research drug discovery drug development metabolic disease alzheimer’s alzheimers diabetes reprofiling

Melior Discovery metabolic

Streptozotocin-Induced Diabetes
Type I diabetes is a condition characterized by loss of insulin producing β-cells of the islets of Langerhans in the pancreas leading to a deficiency in insulin production and secretion. This decrease in insulin leads to a decrease cellular glucose utilization and elevated blood glucose levels. Diabetes can lead to a number of secondary pathologies including retinopathies, neuropathies, nephropathy and cardiomyopathy. Type I diabetes can be modeled by administration of streptozotocin to experimental animals which results in selective destruction of β-cells of the pancreas reducing pancreatic insulin production, decreasing circulating insulin, elevating blood glucose levels and a number of secondary type I diabetes associated pathologies.

                            STZ induced diabetes blood glucose levels

The above data show significantly increased circulating blood glucose levels after treatment with streptozotocin compared to vehicle-treated animals.  Data are mean ± SEM; ***p<0.05 compared to vehicle.

 

If you are interested in learning more about Streptozotocin-Induced Diabetes, please contact models@meliordiscovery.com to start the conversation.