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Melior Discovery motor function

Grip Strength
Rats or mice are placed on a wire grid with either forelimbs alone or forelimb + hindlimb gripping the grid, pulled backward by the tail, and maximal the force the animal exerts at the time of release is recorded (A). This test is a simple and reliable measure of the function of the general motor capability of the animal, in particular function of the spinal motor neurons, efferent axonal conduction, neuromuscular junction, and the muscles themselves.

Figure A- Grip Strength Meter:

                                                                       

                  

Figure B-C: Forelimb and Hindlimb Maximal Force:

                              

 

Grip Strength (grams) in SOD G93A transgenic mice, a well-characterized model of ALS, from 6-18 weeks of age.  The initial decrease in strength in both transgenic and wild type (non-carrier) mice is not unusual (B,C).  It is, however, typical for the transgenic mice to be slightly reduced in strength from the outset of the study.  After 14 weeks, the transgenic mice show a significant rapid loss in muscle strength, whereas grip strength iin the wild type mice is maintained.  Data are mean ± SEM; *p<0.05 compared to wild type mice. 

 

If you are interested in learning more about Grip Strength, please contactmodels@meliordiscovery.com to start the conversation today.