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melior melior melior discovery melior pharmaceuticals preclinical services pre-clinical services in vivo pharmacology in vivo efficacy efficacy models pharmacokinetics indications discovery specialized animal models bioanalytical services theratrace exton pennsylvania cro contract research drug discovery drug development metabolic disease alzheimer’s alzheimers diabetes reprofiling

Melior Discovery pain/neuropathic

Tail-Flick
The tail flick assay measures the latency to thermal pain response and effectiveness of analgesics. 

                          

Thirty minutes prior to drug administration, rats are held on a pre-heated tail flick apparatus.  Once a tail flick response is observed, latency (seconds) to pain response was recorded, with a 15-second time-out period.  After recording pre-treatment (Pre-TX) data, rats were dosed with vehicle, and two concentrations of morphine (1mg/kg or 10mg/kg) and tested at various time points.  Rats dosed with 10 mg/kg morphine had significantly longer pain latency responses compared to vehicle.  Data are mean ± SEM; ***p<0.001 compared to vehicle, +++p<0.001 compared to morphine 1mg/kg dose.

 

If you are interested in learning more about Tail-Flick, please contact models@meliordiscovery.com to start the conversation today.