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Melior Discovery pain/neuropathic

Diabetic Neuropathy- Streptozotocin Insulin Depleted Rats
Type I diabetes is a condition characterized by loss of insulin-producing β-cells of the islets of Langerhans in the pancreas leading to a deficiency in insulin production and secretion. This decrease in insulin leads to decreased cellular glucose utilization and elevated blood glucose levels.

 diabetic neuropathy streptozotocin insulin depleted rats diabetes type I hargreaves paw withdraw von frey mechanical thresholds

The data above displays the development of neuropathies in STZ-treated rats.  Baseline data was collected for Hargreaves paw withdraw to thermal stimulation and von Frey mechanical thresholds.  Latencies to withdraw paws from thermal stimulation are significantly reduced up to four weeks after STZ injection (A).  Rats display a trend in reduced thresholds up to four weeks after STZ injection (B), with significant reductions 1-3 weeks after injection.  Data are mean ± SEM; *p<0.05, **p<0.01, ***p<0.001 compared to baseline.

 

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