melior melior discovery melior pharmaceuticals preclinical services pre-clinical services in vivo pharmacology in vivo efficacy efficacy models pharmacokinetics indications discovery specialized animal models bioanalytical services theratrace exton pennsylvania cro contract research drug discovery drug development metabolic disease alzheimer’s alzheimers diabetes reprofiling
Melior Discovery
home
Therapeutic Areas
Safety Assessment
 

theraTRACE

Melior Pharmaceuticals

              

 

             

 

                 

melior melior melior discovery melior pharmaceuticals preclinical services pre-clinical services in vivo pharmacology in vivo efficacy efficacy models pharmacokinetics indications discovery specialized animal models bioanalytical services theratrace exton pennsylvania cro contract research drug discovery drug development metabolic disease alzheimer’s alzheimers diabetes reprofiling

Melior Discovery pain/neuropathic

Chronic Constrictive Injury
The chronic constriction injury (CCI) model is induced by ligation to the sciatic nerve. Melior has experience in developing several versions, including partial and complete sciatic nerve ligation models.  The CCI model induces a neuropathic pain response that can be detected by von Frey mechanical thresholds and Hargreaves thermal sensitivity, and can be attenuated by administering drugs such as gabapentin, a first-line analgesic for neuropathic pain.

    

Two weeks after CCI, von Frey mechanical thresholds (A) were significantly reduced in vehicle-treated ipsilateral region of the hindpaw compared to contralateral thresholds (Control).  After treatment with Gabapentin, ipsilateral hindpaw thresholds return to baseline and are signficantly increased compared to vehicle-treated ipsilateral thresholds.  In a Hargreaves study of thermal sensitivity, ipsilateral latencies were significantly reduced compared to contralateral latencies in response to heat. Data are mean ± SEM; ***p<0.001 compared to baseline, +++p<0.001 compared to vehicle.

 

If you are interested in learning more about Chronic Constrictive Injury, please contact models@meliordiscovery.com to start the conversation today.