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Melior Discovery psychiatric

Chronic Mild Stress- Corticosterone Assay
Chronic mild stress (CMS) is a paradigm developed in animals to model the relatively minor and unanticipated irritants that lead to a state of anhedonia (an inability to experience pleasure) in some individuals.  Melior has developed a chronic mild stress paradigm that leads to increased behavioral depression and elevated corticosterone levels in rodents. In both instances, these changes are attenuated by treatment with an anti-depressant.

                            

The data above illustrates corticosterone levels following a seven-week chronic mild stressor.  Vehicle-treated animals exhibited significant increases in corticosterone levels compared to unstressed animals.  Animals treated with desipramine, a tricyclic antidepressant, significantly decreased corticosterone levels compared to vehicle-treated animals and were not statistically increased compared to unstressed animals.  This data validates an established rodent model of chronic mild stress that is reversible with desipramine treatment.   Data are mean ± SEM; ***p<0.001compared to unstressed, α p<0.05 compared to vehicle.

 

If you are interested in learning more about Chronic Mild Stress - Corticosterone Levels, please contact models@meliordiscovery.com to start the conversation.