Melior Discovery psychiatric
Chronic Mild Stress- Tail Suspension Behavioral Depression Model
The chronic unpredictable mild stress (CMS) is a paradigm developed in animals to model the relatively minor and unanticipated irritants that lead to a state of anhedonia (an inability to experience pleasure) in some individuals. Here at Melior Discovery, we have developed a chronic mild stress paradigm that leads to increased behavioral depression and elevated corticosterone levels in rodents. In both instances, these changes are attenuated by treatment with an anti-depressant.
The above data illustrate time spent immobile following a seven week chronic mild stressor. Animals treated with desipramine, a tricyclic antidepressant, significantly decreased the amount of time spent immobile compared to vehicle-treated animals. This data validates an established rodent model of chronic mild stress that is reversible with desipramine treatment. Data are mean ± SEM; *p<0.05compared to vehicle.
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