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melior melior melior discovery melior pharmaceuticals preclinical services pre-clinical services in vivo pharmacology in vivo efficacy efficacy models pharmacokinetics indications discovery specialized animal models bioanalytical services theratrace exton pennsylvania cro contract research drug discovery drug development metabolic disease alzheimer’s alzheimers diabetes reprofiling

Melior Discovery psychiatric

Chronic Mild Stress- Tail Suspension Behavioral Depression Model
The chronic unpredictable mild stress (CMS) is a paradigm developed in animals to model the relatively minor and unanticipated irritants that lead to a state of anhedonia (an inability to experience pleasure) in some individuals. Here at Melior Discovery, we have developed a chronic mild stress paradigm that leads to increased behavioral depression and elevated corticosterone levels in rodents. In both instances, these changes are attenuated by treatment with an anti-depressant.
                         

The above data illustrate time spent immobile following a seven week chronic mild stressor.  Animals treated with desipramine, a tricyclic antidepressant, significantly decreased the amount of time spent immobile compared to vehicle-treated animals.  This data validates an established rodent model of chronic mild stress that is reversible with desipramine treatment.  Data are mean ± SEM; *p<0.05compared to vehicle.

 

If you are interested in learning more about Chronic Mild Stress - Tail Suspension, please contact models@meliordiscovery.com to start the conversation.