Melior Discovery psychiatric
Startle Prepulse Inhibition
Pre-pulse inhibition (PPI) is the ability to inhibit the reaction of a subject to a strong startling stimulus (pulse) with a weaker pre-stimulus (pre-pulse). This model is designed to identify pharmacological agents that disrupt sensorimotor gating in normal animals and improve it in affected animals. Neurological disorders associated with sensorimotor gating deficits include schizophrenia, post-traumatic stress disorder, obsessive compulsive disorder, Tourette’s syndrome and Alzheimer’s and Huntington’s Diseases.
The data illustrate a significant reduction in startle amplitude in mice treated with Risperidone compared to mice treated with vehicle. Data are mean ± SEM; **p<0.01 compared to vehicle
If you are interested in learning more about Startle Prepulse Inhibition, please contact firstname.lastname@example.org to start the conversation.