Melior Discovery psychiatric
There are a number of animal models of depression that are used to identify pharmacological agents that have clinical potential as anti-depressant agents. One such animal model is the mouse tail-suspension model. Mice, suspended by the tail, will rapidly develop behavioral despair that is characterized by immobility. This immobility is thought to reflect a state of lowered 'mood' (i.e. depression) in which animals have given up hope of escaping. Tail-suspension immobility is attenuated by a variety of clinically active antidepressants. Antidepressants increase the amount of struggle and the latency until the first extended immobility. This assay is considered to be a good predictor for antidepressant activity and identifies nearly all antidepressant classes including tricyclics, SSRIs, 5-HT1A receptor agonists, and MAOIs.
The data above illustrate the ability of imipramine, a tricyclic antidepressant, to significantly reduce the time spent immobile compared to vehicle-treated animals. Data are mean ± SEM; *p<0.05 compared to vehicle.
If you are interested in learning more about Tail Suspension, please contact firstname.lastname@example.org to start the conversation.