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Melior Discovery psychiatric

Tail Suspension
There are a number of animal models of depression that are used to identify pharmacological agents that have clinical potential as anti-depressant agents. One such animal model is the mouse tail-suspension model. Mice, suspended by the tail, will rapidly develop behavioral despair that is characterized by immobility. This immobility is thought to reflect a state of lowered 'mood' (i.e. depression) in which animals have given up hope of escaping. Tail-suspension immobility is attenuated by a variety of clinically active antidepressants. Antidepressants increase the amount of struggle and the latency until the first extended immobility. This assay is considered to be a good predictor for antidepressant activity and identifies nearly all antidepressant classes including tricyclics, SSRIs, 5-HT1A receptor agonists, and MAOIs.

                              

The data above illustrate the ability of imipramine, a tricyclic antidepressant, to significantly reduce the time spent immobile compared to vehicle-treated animals.  Data are mean ± SEM; *p<0.05 compared to vehicle.

 

If you are interested in learning more about Tail Suspension, please contact models@meliordiscovery.com to start the conversation.