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Social Recognition
Social recognition is an animal model of short-term memory.  this model is based on the fact that adult rats exposed to juvenile rats spontaneously investigate it, and that duration of investigation is a function of the degree of familiarity between the animals.  In this study, we assessed the memory differences between two inter-trial intervals (ITI), the cognitive effects of Armodafinil on short-term memory, and the interaction of adults treated with Armodafinil exposed to novel juveniles. 

             Effects of Armodafinil in Social Recognition Assay

Effects of Armodafinil in Social Recognition Assay.  Adult male rates were placed individually into clean rat cages containing only a microisolator lid, and acclimated for 30 minutes.  After the acclimation period, a juvenile conspecific was placed in the cage and the amount of time that the adult spent investigating the juvenile was recorded over a five minute priod (Trial 1). Investigative behavior included sniffing, close following, grooming and fighting (aggresion).  After five minutes, both rats were returned to their home cages.  The adult rat was then dosed with vehicle or Armodafinil 90 minutes after the first exposure, replaced into the test cage and reacclimated for 30 minutes before the start of Trial 2.  During Trial 2, either the same juvenile (F - familiar) or a novel juvenile (N - novel) was replaced in the test cage and social investigation was recorded.  After a two hour interexposure interval (IEI), untreated rats do not retain the memory of the juvenile.  Memory enhancing compound effects were detected in Armodafinil with a familiar juvenile rat (Armod + F) compared to Armodafinil with a novel juvenile rat (Armod + N) in Trial 2, 120 minutes after Trial 1. 

 

If you are interested in learning more about Social Recognition, please contact models@meliordiscovery.com to start the conversation.