Melior Discovery psychiatric
Hyponeophagia Stress-Induced Anxiety Model
Hyponeophagia – the phenomenon in which exposure to a novel environment suppresses feeding behavior – can be used as an assessment of anxiety in animals. Here at Melior Discovery we have developed a novel environment induced feeding suppression assay (NEIFS) measuring the latency to eat. This test assesses stress-induced anxiety and as such can be used to screen compounds that may have anxiolytic or antidepressant efficacy.
Imipramine, a tricyclic antidepressant, significantly decreases the latency to feed in a novel environment. Data are mean ± SEM; **p<0.01 compared to vehicle.
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