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melior melior melior discovery melior pharmaceuticals preclinical services pre-clinical services in vivo pharmacology in vivo efficacy efficacy models pharmacokinetics indications discovery specialized animal models bioanalytical services theratrace exton pennsylvania cro contract research drug discovery drug development metabolic disease alzheimer’s alzheimers diabetes reprofiling

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Rotarod
The rotarod test is a simple pharmacological assessment of motor coordination, balance, muscle strength and gait, as well as sensory. In addition to straightforward assessment of coordinated movement, data from rotarod performance experiments can also be beneficial for interpreting results from other behavioral models.  Specifically, many drugs that have either sedative or stimulant properties could interfere with assessment of behavioral tests that require a motoric response.  Consequently, having an “a-priori” read on locomotor coordination effects of the novel compounds is prudent, if not necessary for planning, executing and explaining behavioral results gathered during standard pre-clinical efficacy profiling. 

                      

The above graph illustrates the effects of haloperidol, a typical antipsychotic known to affect motor coordination known to disrupt motor coordination at high doses. Initially, prior to haloperidol treatment, both groups of mice had similar motor coordination (0 hours post dose). One hour after haloperidol treatment motor coordination is significantly impaired compared to vehicle-treated animals.  Data are mean ± SEM; *p<0.05, **p<0.01, ***p<0.001 compared to vehicle.

 

If you are interested in learning more about Rotarod, please contact models@meliordiscovery.com to start the conversation.