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Melior Discovery psychiatric

Forced Swim Test and Depression Model
The forced swim test is a commonly used assay for detecting anti-depressant activity of pharmacological agents. When mice are required to swim in a container with no route of escape, they develop a behavioral despair that is characterized by immobility except for small movements needed to remain afloat. This immobility is thought to reflect a state of lowered 'mood' (i.e. depression) in which animals have given up "hope" of escaping.

Forced swim is attenuated by a variety of clinically active antidepressants. Antidepressants increase the amount of struggle and the latency until the first extended immobility. This assay is considered to be a good predictor for antidepressant activity and identifies nearly all antidepressant classes including tricyclics, SSRIs, 5-HT1A receptor agonists, and MAOIs.
                               

The data above illustrate the effects of imipramine, a tryicyclic antidepressant, in the forced swim test. Imipramine dose dependently decreased the time spent immobile relative to vehicle treated animals.  The decrease in immobility has been found to be predictive of antidepressant effects in the clinic.   Data are mean ± SEM; **p<0.01, ***p<0.001 compared to vehicle.

 

If you are interested in learning more about the Forced Swim Test, please contact models@meliordiscovery.com to start the conversation.