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melior melior melior discovery melior pharmaceuticals preclinical services pre-clinical services in vivo pharmacology in vivo efficacy efficacy models pharmacokinetics indications discovery specialized animal models bioanalytical services theratrace exton pennsylvania cro contract research drug discovery drug development metabolic disease alzheimer’s alzheimers diabetes reprofiling

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Vogel Water Conflict and Anxiety Model
Anxiety is a psychological and physiological state characterized by learning and memory, emotional, and behavioral components. The Vogel water conflict assay is used to identify drugs that have anxiolytic (alleviate anxiety) potential. By punishing drinking behavior with a mild electric shock animal will decrease drinking behavior. Many different classes of antidepressant drugs will re-establish drinking behavior. As such, the Vogel water conflict can be used to screen test compounds for anxiolytic activity.

                            

The data above depicts diazepam's ability, as a tricyclic antidepressant, to increase the quantity of shocks tolerated to alleviate thirst and re-establish drinking behavior.  Data are mean ± SEM; *p<0.05 compared to vehicle.

If you are interested in learning more about Vogel Water Conflict, please contact models@meliordiscovery.com to start the conversation.