Melior Discovery psychiatric
Vogel Water Conflict and Anxiety Model
Anxiety is a psychological and physiological state characterized by learning and memory, emotional, and behavioral components. The Vogel water conflict assay is used to identify drugs that have anxiolytic (alleviate anxiety) potential. By punishing drinking behavior with a mild electric shock animal will decrease drinking behavior. Many different classes of antidepressant drugs will re-establish drinking behavior. As such, the Vogel water conflict can be used to screen test compounds for anxiolytic activity.
The data above depicts diazepam's ability, as a tricyclic antidepressant, to increase the quantity of shocks tolerated to alleviate thirst and re-establish drinking behavior. Data are mean ± SEM; *p<0.05 compared to vehicle.
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