Melior Discovery psychiatric
Stress and general emotional state can have a multitude of effects on the body as the two are inextricably linked via the hypothalamic–pituitary–adrenal axis (HPA axis). Thus, changes in physiology, such as temperature, can be indicative of changes in stress. When exposed to brief periods of stress rodents display an increase in body temperature (hyperthermia). Many classes of antidepressant drugs can attenuate stress-induced hyperthermia. Here at Melior Discovery, our stress-induced hyperthermia assay offers a quick way to screen for anxiolytic potential in test compounds.
The data above illustrate the effects of diazepam, a tricyclic antidepressant, on body temperature following a brief stress. While vehicle-treated animals exhibited an increase in core body temperature, diazepam treated animals exhibited significantly reduced change in body temperature.
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