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Melior Discovery psychiatric

Elevated Plus Maze Anxiety Assay
The Elevated Plus Maze (EPM) is an anxiety assay for putative anxiolytic (alleviating anxiety) or anxiogenic (anxiety inducing) compounds. The test involves a plus-shaped maze with two open and two enclosed arms. The model relies on the rodent’s tendency to hide in enclosed spaces.  Anxiety reduction in this model is measured by an increase in the amount of time spent in the open arms.  Anxiolytic drugs that increase GABAergic transmission are reliably effective in this model.

                            

The data above depict the ability of diazepam, a tricyclic antidepressant, to reduce anxiety and increase the amount of time spent in the open arm of the maze compared to vehicle treated animals. Data are mean ± SEM; ***p<0.001 compared to vehicle.

 

If you are interested in learning more about the Elevated Plus Maze, please contact models@meliordiscovery.com to start the conversation.