melior melior discovery melior pharmaceuticals preclinical services pre-clinical services in vivo pharmacology in vivo efficacy efficacy models pharmacokinetics indications discovery specialized animal models bioanalytical services theratrace exton pennsylvania cro contract research drug discovery drug development metabolic disease alzheimer’s alzheimers diabetes reprofiling
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High Throughput In Vivo Pharmacology:
Our Technology
 
 

 

 

melior melior melior discovery melior pharmaceuticals preclinical services pre-clinical services in vivo pharmacology in vivo efficacy efficacy models pharmacokinetics indications discovery specialized animal models bioanalytical services theratrace exton pennsylvania cro contract research drug discovery drug development metabolic disease alzheimer’s alzheimers diabetes reprofiling

Our Technology platform efficiency

Melior believes that the ideal molecules to enter the theraTRACE® platform are mid- to late-stage clinical compounds previously discontinued for reasons other than safety. Such "privileged" and safe compounds may be relatively few in number, but are considered high-value assets. Given the significant investment already made in these drug candidates, an ideal repositioning platform should have very low error rates and would therefore not benefit from the high throughput potentially offered by in silico systems. These valuable compounds may only be evaluated optimally by using in vivo drug discovery approaches.

For these reasons, Melior's theraTRACE® platform offers the most cost-effective strategy for screening a compound through a series of in vivo models. The platform offers a high quality, multiplexed tool with low error rates for detecting new indications. These are the same high quality in vivo models that are used to determine whether a candidate demonstrates sufficient efficacy to merit advancement into the clinic.

 

If you are interested in learning more about platform efficiency, please contact bizdev@meliordiscovery.com to start the conversation.