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Melior Pharmaceuticals

melior melior melior discovery melior pharmaceuticals preclinical services pre-clinical services in vivo pharmacology in vivo efficacy efficacy models pharmacokinetics indications discovery specialized animal models bioanalytical services theratrace exton pennsylvania cro contract research drug discovery drug development metabolic disease alzheimer’s alzheimers diabetes reprofiling

Melior Discovery drug abuse liability

Self Administration
Drug self-administration in animals is the “gold standard” preclinical procedure for measuring the reinforcing (i.e. rewarding/aversive) effects of drugs.  This animal model is widely used for preclinical evaluation and screening of novel pharmaceutical products for drug abuse potential as well as in the treatment of drug abuse and dependence. In this paradigm, subjects are trained to press a lever which results in the delivery of a drug “reinforcer”.  The salience of the drug reinforcement, or abuse potential, can be determined.   Basic research studies suggest that the underlying pharmacological mechanisms and neural circuitries mediating the reinforcing properties of drugs in animals overlap considerably with those mediating the abuse related effects of drugs in humans.  More than 20 psychoactive drugs that are abused by humans function as “reinforcers” in rats, supporting the hypothesis that drug SA in animals is a reliable predictor of abuse liability in humans.

                  

                  

 

If you are interested in learning more about Self Administration, please contact models@meliordiscovery.com to start the conversation.