Melior Discovery seizure potential
Epileptic seizures are effectively modeled in experimental animals using several methods including maximal electroshock, kindling methods and chemically - induced seizures. Pentylenetetrazole (PTZ), a GABA receptor agonist, is a common chemically induced seizure model. When PTZ is administered to mice, it produces a myoclonic seizure that models absense (petit mal) seizures. Compounds that enhance GABAergic transmission are effective in ameliorating seizure activity induced by PTZ.
After a 24-hour fast, mice were injected with Vehicle or Diazepam (30mg/kg) 15 minutes prior to PTZ administration. After PTZ was administered, the time until the first whole-body clonus event and time to the tonic-hind limb extension were calculated. A-B) Diazepam significantly delayed the onset of the myoclonic seizure and the onset of the tonic hindlimb extensor response until at least the 5 minute time-out. Data are mean
± SEM; **p<0.01, ***p<0.001 compared to Vehicle.
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