Melior Discovery Collaborative Publications

Nanoparticle-based inhibition of vascular endothelial growth factor receptors alleviates osteoarthritis pain and cartilage damage
Kaige Ma, Tiep Pham, Jun Wang, InSug O-Sullivan, Amy DiCamillo, Shiyu Du, Fackson Mwale, Zeba Farooqui, Gina Votta-Velis, Benjamin Bruce, Andre J van Wijnen, Ying Liu, Hee-Jeong Im
Sci Adv. 2024 Feb 16;10(7):eadi5501. doi: 10.1126/sciadv.adi5501. Epub 2024 Feb 14

A PDK-1 allosteric agonist improves spatial learning and memory in a βAPP/PS-1 transgenic mouse-high fat diet intervention model of Alzheimer’s disease
Quefurth H, Slitt A, DiCamillo A, Surles N, DeBoef B, Lee H-K.
Behav. Brain Res. 2023 Feb 13:438:114183. doi: 10.1016/j.bbr.2022.114183

Intravenously Administered Ganaxolone Blocks Diazepam-Resistant Lithium-Pilocarpine-Induced Status Epilepticus in Rats: Comparison with Allopregnanolone
Saporito MS, Gruner JA, DiCamillo A, Hinchliffe R, Barker-Haliski M and White HS.
J. Pharmacol. Exp. Therap. 2019 Mar; 368(3):326-337

Translating Alcohol Research:  Opportunities and Challenges
Batman AM, Miles MF
Alcohol Research 2015;37(1):7-14.

ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice.
Naydenov AV, Horne EA, Cheah CS, Swinney K, Hsu KL, Cao JK, Marrs WR, Blankman JL, Tu S, Cherry AE, Fung S, Wen A, Li W, Saporito MS, Selley DE, Cravatt BF, Oakley JC, Stella N.
Neuron. 2014 Jul 16;83(2):361-71.

Anticonvulsant activity of pregabalin in the maximal electroshock-induced seizure assay in α2δ1 (R217A) and α2δ2 (R279A) mouse mutants.
Lotarski S, Hain H, Peterson J, Galvin S, Strenkowski B, Donevan S, Offord J.
Epilepsy Res. 2014 Jul;108(5):833-42.

ADX71441, a novel, potent and selective positive allosteric modulator of the GABA(B) receptor, shows efficacy in rodent models of overactive bladder.
Kalinichev M, Palea S, Haddouk H, Royer-Urios I, Guilloteau V, Lluel P, Schneider M, Saporito M, Poli S.
Br J Pharmacol. 2014 Feb;171(4):995-1006.

Discovery of high potency, single-chain insulin analogs with a shortened B-chain and nonpeptide linker.
Kaur ZP, Ochman AR, Mayer JP, Gelfanov VM, DiMarchi RD.
ACS Chem Biol. 2013 Aug 16;8(8):1822-9.

Possible therapeutic effect of trilostane in rodent models of inflammation and nociception.
Tung D, Ciallella J, Hain H, Cheung PH, Saha S.
Curr Ther Res Clin Exp. 2013 Dec;75:71-6.

Novel anti-inflammatory effects of doxazosin in rodent models of inflammation.
Tung D, Ciallella J, Cheung PH, Saha S.
Pharmacology. 2013;91(1-2):29-34.

Effect of the antipsychotic agent amisulpride on glucose lowering and insulin secretion.
Roix JJ, DeCrescenzo GA, Cheung PH, Ciallella JR, Sulpice T, Saha S, Halse R.
Diabetes Obes Metab. 2012 Apr;14(4):329-34.

Synthesis and pharmacological evaluation of N-(-3-(1H-indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl) methanesulfonamide (LP-261), a potent antimitotic agent.
Shetty RS, Lee Y, Lui B, Husain A, Joseph RW, Lu Y, Nelson D, Mihelcic J, Chao W, Moffett KK, Shumacher A, Flubacher D, Stojanovic A, Bukhtiyarova M, Williams K, Lee KJ, Ochman AR, Saporito MS, Moore WR, Flynn GA, Dorsey BD, Springman EB, Fujimoto T, Kelly MJ.
J Med Chem. 2011 Jan 14; 54(1): 179-200.

Anti-inflammatory and immunomodulatory effects of bortezomib in various in-vivo models.
Tung D, Cheung PH, Kaur P, Foreman O, Kavirayani A, Hain HS, Saha S.
Pharmacology. 2011;88(1-2):100-13.

Novel anti-inflammatory effects of repaglinide in rodent models of inflammation.
Tung D, Cheung PH, Ciallella J, Saha S.
Pharmacology. 2011;88(5-6):295-301.

Derivatives of human complement component C3 for therapeutic complement depletion: a novel class of therapeutic agents.
Tung D, Cheung PH, Ciallella J, Saha S.
Pharmacology. 2011;88(5-6):295-301.

Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronapthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-linage kinase 1 crystallography, and oral in-vivo activity in 1-methyl-4-phenyltetrahydropyridine models.
Hudkins RL, Diebold JL, Tao M, Josef KA, Park CH, Angeles TS, Aimone LD, Husten J, Ator MA, Meyer SL, Holskin DP, Durkin JT, Fedorov AA, Fedorov EV, Almo SC, Mathiasen JR, Bozyczko-Coyne D, Saporito MS, Scott RW, Mallamo JP.
J Med Chem. 2008 Sep 25; 51(18):5680-9.

An extensive phenotypic characterization of the hTNFalpha transgenic mice.
Hayward MD, Joes BK, Saparov A, Hain HS, Trillat AC, Bunzel MM, Coron A, Li-Wang B, Strenkowski B, Giordano C, Shen H, Arcamone E, Weidlick J, Vilensky M, Tugusheva M, Felkner RH, Campbell W, Rao Y, Grass DS, Buiakova O. 
BMC Physiol. 2007 Dec 10; 7:13.

Phenotypes of mice lacking extracellular superoxide dismutase and copper- and zinc-containing superoxide dismutase.
Sentman ML, Granstrom M, Jakobson H, Reaume A, Basu S, Marklund SL. 
J Biol Chem. 2006 Mar 17; 281(11):6904-9.