Bioanalysis

Discover how Melior’s unique phenotypic screening platforms can uncover the untapped value of your candidate therapeutic

Bioanalysis capabilities allow for quantitation of small molecule concentrations (e.g. drug levels) in biological samples (e.g. blood) using HPLC with tandem mass spectroscopy (LC/MS/MS). Several samples types are handled including brain (whole, dissected brain regions, punches), whole blood or plasma, CSF, peripheral organs.

Melior Discovery offers bioanalysis services in collaboration with our partner, Keystone Bioanalytical (North Wales, PA). Melior has been working with Keystone since our inception in 2005. They are our chosen partner because of their high reliability, fast turn around, and reasonable cost.

Melior works with Keystone as a subcontracted service to provide the bioanalytical components of a study in a turnkey solution to our clients. All bioanalytical data is integrated into our final study reports.

Applications:

Pharmacokinetic studies
Drug exposure
Brain neurochemistry
Measurement of exogenous compounds
Measurement of drug metabolites

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This model is 1 of more than 60 models included in our theraTRACE^® platform

Ready to get started or looking for a custom model?

Contact us today for more information about our bespoke research models and to discuss how we can help you answer your unique research questions.

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Frequently Asked Questions

Do you have the ability to perform the LC/MS/MS analysis?

Yes. We work closely with Keystone Bioanalytical who has the ability to analyze blood and other tissue samples.

Can bioanalysis be performed as part of a larger study?

Yes. Terminal collection of plasma, serum, whole blood, or other tissues can be performed and be sent for bioanalysis. Alternatively, blood or tissue can be collected at specific timepoints for analysis. Our scientists would be more than happy to discuss the feasibility of perform bioanalysis within a larger study.

Synonyms: PK, Pharmacodynamics, Pharmacokinetics

Interested in running a Bioanalysis study?

If you are interested in learning more about the Bioanalysis, please contact us to start the conversation today!

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We chose Melior Discovery because they were responsive and cost effective. We are staying with them as a chosen scientific partner because of their thoughtful scientific input to experimental design and attention to detail. Their expertise and flexibility allowed us to quickly adapt the study design and evaluate additional outcome measures to pursue unexpected activity.
Sridharan Rajamani, Ph.D., Senior Research Scientist
Gilead Sciences
I have been working with Melior on a number of projects over the course of a few years now. They have been a great partner throughout this time. The scientists whom I have worked with have been great problem-solvers and were customer focused.
Jay Lichter
Avalon Ventures
Melior provided State-of-the-art Preclinical Pharmacology Support for a period of nearly a year where a series of in vivo studies were completed on a weekly basis. The staff was extremely user-friendly and the operational processes were excellent. I can recommend Melior without reservation.
Richard DiMarchi, PhD
Cox Professor of Chemistry & Gill Chair in Biomolecular Sciences Indiana University, Department of Chemistry
Because Melior could do the orthotopic intracranial implants, we were able to do survival studies with brain tumor-bearing animals that were treated with our therapy, showing a beautiful survival with our agent versus control. Talk about something that gets your investors going! These beautiful survival curves with our agent versus control and visual photos are in all of our investor decks because… it's powerful.
Bruce Ruggeri, Ph.D.
Modifi Bio
Melior works in many therapeutic areas, like CNS, inflammatory disease, GI, cardiovascular, and oncology. I was very pleased that when it came to doing tumor studies, both subcutaneous and intracranial, they did them well. They reported on the studies on time and did the data analysis really well.
Bruce Ruggeri, Ph.D.
Modifi Bio
Their areas of expertise are extensive, and they are very experienced, responsive, and flexible in terms of how the study is run. Their pricing is reasonable, making them the best option for a young, not well-funded company like ours.
Maxine Gowen
Tamuro Bio
Melior’s team was very experienced and knowledgeable. They were always very open to suggestions and questions, spending a lot of time helping us feel comfortable with the study design. I would give them very high marks.
Maxine Gowen
Tamuro Bio
The most important factors in choosing to work with Melior were the fit between the tests they could run and our needs, as well as their tight budget and proximity. Melior was the best fit for our research goals.
Ira Spector
SFA Therapeutics