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Melior Discovery inflammation/arthritis
Contact Hypersensitivity Five days after baseline and initial sensitization to either oxazolone or DNFB, animals are administered compound and challenged with hapten. Any resulting sensitivity (i.e: swelling and/or redness) is mechanically measured and visually scored 24 hours after the challenge.
The figures illustrate the visual scoring (0 = no swelling or redness; 1 = minor swelling or redness; 2 = moderate swelling and some redness; 3 = severe swelling and prominent redness) and the tissue thickness after the challenge. Both agents produced an allergic reaction measured as tissue swelling and visual score.
Dexamethasone significantly attenuated the allergic reaction compared to vehicle-treated animals (***p<0.001). Data are mean ± SEM; ***p<0.001 compared to vehicle. If you are interested in learning more about Contact Hyperesensitivity, please contact models@meliordiscovery.com to start the conversation. |
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