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Melior Discovery neurology Experimental Autoimmune Encephalomyelitis (EAE) Model of Multiple Sclerosis Figure A: Body weights. The untreated mice showed an increase in body weight throughout the study. The FTY-720 and vehicle treated mice displayed a decrease in body weights following injection of PLP/CFA, which was maintained throughout the study.
Figure B: Average clinical scores over time. Clinical scores were assessed daily beginning on Day 7 and ending on Day 21. Based on the clinical score system, vehicle treated mice showed an increase in impairment severity throughout the course of the study. The FTY-720 treated mice showed a decrease in impairment following drug administration that became statistically significant when compared to vehicle treated mice on days 17-21. Data are mean ± SEM; * p<0.05, **p<0.01 compared to vehicle.
Clnical Scoring: Mice were randomized according to clnical score on Day 7 of the study. Clnical scoring was completed so that each mouse received one score per day. Clnical scores were evaluated using the following scale:
If you are interested in learning more about the EAE Model of Multiple Sclerosis, please contactmodels@meliordiscovery.com to start the conversation.
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