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Melior Discovery neurophysiology Motor Evoked Potentials and Nerve Conduction Figure A- CMAP in SOD1 +/+ vs -/- Mice: Responses in the plantar foot muscle to stimulation of the sciatic verve at the hip and the tibial nerve at the ankle in SOD knockout (-/-) versus wild type (+/+) mice. Note the relatively delayed response latency (indicating slower conduction) and reduced muscle response in amplitude in the knockout mice (Flood et al, 1999).
Figure B- CMAP versus Behavior Scores, SOD Transgenic Mice: Plantar foot muscle responses evoked by stimulation of the tibial nerve were recorded from G93A SOD transgenic and non-transgenic control mice biweekly from 8-16 weeks. A significant difference was seen at all time points. Hindlimb behavior scores, however, were not different until 16 weeks. *p<0.05, unpaired t-test; n=10-12/group.
Figure C- CMAP Time Course, SOD G93A Mice: Responses to tibialis anterior to sciatic nerve stimulation in G93A SOD transgenic versus non-transgenic control mice weekly from 5-17 weeks. A significant difference in CMAP amplitude was seen as early as 7 weeks. *p<0.05, unpaired t-test; n=12/group.
If you are interesed in learning more about Motor Evoked Potentials and Nerve Conduction, please contact models@meliordiscovery.com to start the conversation.
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