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 melior melior melior discovery melior pharmaceuticals preclinical services pre-clinical services in vivo pharmacology in vivo efficacy efficacy models pharmacokinetics indications discovery specialized animal models bioanalytical services theratrace exton pennsylvania cro contract research drug discovery drug development metabolic disease alzheimer’s alzheimers diabetes reprofiling

Melior Discovery urogenital

Micturition : Diet-Induced Stress and Overactive Bladder
Micturition is a parasympathetic function of the nervous system and is achieved by complex neurological mechanisms involving the somatic, autonomic and central components of the urinary system.  Micturition disorders are classified as disturbances in bladder storage or emptying.  The failure to store urine leads to urgent and stress-related incontinence. This study validates a micturition assay in which latency to urinate and urination volume were produced by an oxybutynin challenge and measured using an automated collection chamber.

After a 24-hour fast, mice were injected with vehicle and 1.0 mL water subcutaneously.  Oxybutynin (100mg/kg) was orally administered 5 minutes after water administration and mice were placed in the automated chambers for 90 minutes.  Oxybutynin caused a significant increase in latency for first urination event (A) as well as a reduction in urination volume (B).  Data are mean ± SEM; **p<0.01, ***p<0.001 compared to vehicle.

 

If you are interested in learning more about Micturition: Diet-Induced Stress and Overactive Bladder, please contact models@meliordiscovery.com to start the conversation.